The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter
The cytosolic acyl-coenzyme A thioesterase I (Acot1) is an enzyme that hydrolyzes long-chain acyl-CoAs of C12-C20-CoA in chain length to the free fatty acid and CoA. Acot1 was shown previously to be strongly upregulated at the mRNA and protein level in rodents by fibrates. In this study, we show tha...
Main Authors: | Bikesh Dongol, Yatrik Shah, Insook Kim, Frank J. Gonzalez, Mary C. Hunt |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2007-08-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520425143 |
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