Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells

Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells

Abstract Background and Aims The activating mutation BRAFV600E is a frequent genetic event in papillary thyroid carcinomas (PTC). Mutation BRAFV600E is associated with the loss of a sodium/iodine symporter (NIS), and subsequent radioiodide-refractory (RAI) metastatic disease. Use of BRAF V600E inhib...

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Bibliographic Details
Main Authors: Honglai Zhang, Dong Chen
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Thyroid Research
Subjects:
Papillary thyroid carcinoma
Assodium/iodide symporter
Mutation BRAFV600E
Mitogen-activated protein kinase
Online Access:http://link.springer.com/article/10.1186/s13044-018-0057-6

Internet

http://link.springer.com/article/10.1186/s13044-018-0057-6

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