Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS

Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS

The outcome of the recent Antibody Mediated Prevention (AMP) trials that tested infusion of the broadly neutralizing antibody (bnAb) VRC01 provides proof of concept for blocking infection from sensitive HIV-1 strains. These results also open up the possibility that triple combinations of bnAbs such...

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Bibliographic Details
Main Authors: Martina S. Wesley, Kelvin T. Chiong, Kelly E. Seaton, Christine A. Arocena, Sheetal Sawant, Jonathan Hare, Kasey Hernandez, Michelle Rojas, Jack Heptinstall, David Beaumont, Katherine Crisafi, Joseph Nkolola, Dan H. Barouch, Marcella Sarzotti-Kelsoe, Georgia D. Tomaras, Nicole L. Yates
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
antibody
immunoprophilaxis
HIV - human immunodeficiency virus
pharmacokinetics
validation
broadly neutralizing antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.709994/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.709994/full

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