Impaired Metabolic Flexibility in the Osteoarthritis Process: A Study on Transmitochondrial Cybrids

Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular energy demand, but studies implicate impaired mitochondrial function in OA pathogenesis. The relationship between mitochondrial dysfuncti...

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Bibliographic Details
Main Authors: Andrea Dalmao-Fernández, Jenny Lund, Tamara Hermida-Gómez, María E Vazquez-Mosquera, Ignacio Rego-Pérez, Francisco J. Blanco, Mercedes Fernández-Moreno
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/9/4/809