Validation of Single Nucleotide Variant Assays for Human Leukocyte Antigen Haplotypes HLA-B*15:02 and HLA-A*31:01 Across Diverse Ancestral Backgrounds

Validation of Single Nucleotide Variant Assays for Human Leukocyte Antigen Haplotypes HLA-B*15:02 and HLA-A*31:01 Across Diverse Ancestral Backgrounds

The human leukocyte antigen haplotypes HLA-B*15:02 and HLA-A*31:01 have been linked to life-threatening adverse drug reactions to the anticonvulsants carbamazepine and oxcarbazepine. Identification of these haplotypes via pharmacogenetic techniques facilitates implementation of precision medicine to...

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Bibliographic Details
Main Authors: Amanda Buchner, Xiuying Hu, Katherine J. Aitchison
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
HLA antigens
adverse drug reactions
carbamazepine
psychiatry
pharmacogenetics
precision medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.713178/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.713178/full

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