ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis

ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis

Abstract Background The small GTPase ARF1 mediates membrane trafficking mostly from the Golgi, and is essential for the G protein-coupled receptor (GPCR)-mediated chemotaxis of neutrophils. In this process, ARF1 is activated by the guanine nucleotide exchanger GBF1, and is inactivated by the GTPase-...

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Bibliographic Details
Main Authors: Yuichi Mazaki, Yasuhito Onodera, Tsunehito Higashi, Takahiro Horinouchi, Tsukasa Oikawa, Hisataka Sabe
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Cell Communication and Signaling
Subjects:
Chemotaxis
ARF1
GBF1
RAC1
Online Access:http://link.springer.com/article/10.1186/s12964-017-0193-y

Internet

http://link.springer.com/article/10.1186/s12964-017-0193-y

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