Raft-like microdomains play a key role in mitochondrial impairment in lymphoid cells from patients with Huntington's disease

Raft-like microdomains play a key role in mitochondrial impairment in lymphoid cells from patients with Huntington's disease

Huntington's disease (HD) is a genetic neurodegenerative disease characterized by an exceedingly high number of contiguous glutamine residues in the translated protein, huntingtin (Htt). The primary site of cell toxicity is the nucleus, but mitochondria have been identified as key components of...

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Bibliographic Details
Main Authors: Laura Ciarlo, Valeria Manganelli, Paola Matarrese, Tina Garofalo, Antonella Tinari, Lucrezia Gambardella, Matteo Marconi, Maria Grasso, Roberta Misasi, Maurizio Sorice, Walter Malorni
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Journal of Lipid Research
Subjects:
rafts
mitochondria
fission
huntingtin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520431839

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http://www.sciencedirect.com/science/article/pii/S0022227520431839

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