The t(14;18) translocation is absent from endothelial and follicular dendritic cells of follicular lymphoma (FL) and shows heterogeneous presence in preserved FL mantle zones

The t(14;18) translocation is absent from endothelial and follicular dendritic cells of follicular lymphoma (FL) and shows heterogeneous presence in preserved FL mantle zones

Abstract Background The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85–90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phenotype or can be observed in other cell types of the microenvironment re...

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Bibliographic Details
Main Authors: Perikles Kosmidis, Barbara Mankel, Falko Fend, Patrick Adam
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Diagnostic Pathology
Subjects:
T(14;18)
Microenvironment cells
Follicular lymphoma
Online Access:http://link.springer.com/article/10.1186/s13000-018-0703-2

Internet

http://link.springer.com/article/10.1186/s13000-018-0703-2

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