Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown. We investigated key elements of the complement system during bacterial infections in pati...

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Bibliographic Details
Main Authors: László József Barkai, Emese Sipter, Dorottya Csuka, Zoltán Prohászka, Katrine Pilely, Peter Garred, Nóra Hosszúfalusi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
ficolin-3
lectin pathway
alternative pathway
classical pathway
complement
type 2 diabetes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00509/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00509/full

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