Cross-sectional analysis of circulating tumor DNA in primary colorectal cancer at surgery and during post-surgery follow-up by liquid biopsy

Cross-sectional analysis of circulating tumor DNA in primary colorectal cancer at surgery and during post-surgery follow-up by liquid biopsy

Abstract Background Liquid biopsy (LB) in early-stage, non-metastatic colorectal cancer (CRC) must be sensitive enough to detect extremely low circulating tumor DNA (ctDNA) levels. This challenge has been seldom and non-systematically investigated. Methods Next generation sequencing (NGS) and digita...

Full description

Bibliographic Details
Main Authors: Matteo Allegretti, Giuliano Cottone, Fabio Carboni, Ettore Cotroneo, Beatrice Casini, Elena Giordani, Carla Azzurra Amoreo, Simonetta Buglioni, Maria Diodoro, Edoardo Pescarmona, Settimio Zazza, Orietta Federici, Massimo Zeuli, Laura Conti, Giovanni Cigliana, Francesco Fiorentino, Mario Valle, Patrizio Giacomini, Francesca Spinella
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal carcinoma
Liquid biopsy
Circulating tumor DNA
Next generation sequencing
Digital PCR
Online Access:http://link.springer.com/article/10.1186/s13046-020-01569-z

Internet

http://link.springer.com/article/10.1186/s13046-020-01569-z

Similar Items