Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine

Live attenuated influenza vaccines (LAIV) have prevented morbidity and mortality associated with influenza viral infections for many years and represent the best therapeutic option to protect against influenza viral infections in humans. However, the development of LAIV has traditionally relied on e...

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Bibliographic Details
Main Authors: Luis Martínez-Sobrido, Olve Peersen, Aitor Nogales
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/10/10/560