Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease

Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease

White matter (WM) alterations have been identified as a relevant pathological feature of Huntington’s disease (HD). Increasing evidence suggests that WM changes in this disorder are due to alterations in myelin‐associated biological processes. Multi-compartmental analysis of the complex gradient-ech...

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Bibliographic Details
Main Authors: Chiara Casella, Elena Kleban, Anne E. Rosser, Elizabeth Coulthard, Hugh Rickards, Fabrizio Fasano, Claudia Metzler-Baddeley, Derek K. Jones
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Frequency difference mapping
Three-pool model
Premanifest Huntington’s disease
Myelin
Executive function
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158221001029

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http://www.sciencedirect.com/science/article/pii/S2213158221001029

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