Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

Breast cancer heterogeneity in histology and molecular subtype influences metabolic and proliferative activity and hence the acid load on cancer cells. We hypothesized that acid-base transporters and intracellular pH (pHi) dynamics contribute inter-individual variability in breast cancer aggressiven...

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Bibliographic Details
Main Authors: Nicolai J Toft, Trine V Axelsen, Helene L Pedersen, Marco Mele, Mark Burton, Eva Balling, Tonje Johansen, Mads Thomassen, Peer M Christiansen, Ebbe Boedtkjer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
acid-base
luminal A breast cancer
metastasis
microenvironment
proliferation
triple-negative breast cancer
Online Access:https://elifesciences.org/articles/68447

Internet

https://elifesciences.org/articles/68447

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