Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease

Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease

Background: Mediastinal ionizing radiotherapy is associated with an increased risk of valvular disease, which demonstrates pathological hallmarks similar to calcific aortic valve disease (CAVD). Despite advances in radiotherapy techniques, the prevalence of comorbidities such as radiation-associated...

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Bibliographic Details
Main Authors: Manon Meerman, Rob Driessen, Nicole C. A. van Engeland, Irith Bergsma, Jacco L. G. Steenhuijsen, David Kozono, Elena Aikawa, Jesper Hjortnaes, Carlijn V. C. Bouten
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
aortic valve disease
radiotherapy
extracellular matrix
in vitro modeling
valvular interstitial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.687885/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.687885/full

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