Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function

Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function

ObjectivesPsoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Janus Kinase inhibitors (JAKi) have emerged as an encouraging class of drugs for the treatment of PsA. Here, we compare the effect of four JAKi on primary PsA synovial fibroblasts (PsAFLS) activation, me...

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Bibliographic Details
Main Authors: Aisling O’Brien, Megan Mary Hanlon, Viviana Marzaioli, Siobhan C. Wade, Keelin Flynn, Ursula Fearon, Douglas J. Veale
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
psoriatic arthritis
metabolism
JAK-STAT (janus kinase-signal transducer and activators of transcription)
synovial fibroblast
synovial invasion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.672461/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.672461/full

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