Toll-like receptor dual-acting agonists are potent inducers of PBMC-produced cytokines that inhibit hepatitis B virus production in primary human hepatocytes

Toll-like receptor dual-acting agonists are potent inducers of PBMC-produced cytokines that inhibit hepatitis B virus production in primary human hepatocytes

Abstract Recombinant interferon-α (IFN-α) treatment functionally cures chronic hepatitis B virus (HBV) infection in some individuals and suppresses virus replication in hepatocytes infected in vitro. We studied the antiviral effect of conditioned media (CM) from peripheral blood mononuclear cells (P...

Full description

Bibliographic Details
Main Authors: Vaclav Janovec, Jan Hodek, Kamila Clarova, Tomas Hofman, Pavel Dostalik, Jiri Fronek, Jaroslav Chlupac, Laurence Chaperot, Sarah Durand, Thomas F. Baumert, Iva Pichova, Barbora Lubyova, Ivan Hirsch, Jan Weber
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-69614-7

Internet

https://doi.org/10.1038/s41598-020-69614-7

Similar Items