RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockadeResearch in context

RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockadeResearch in context

Background: Antibody-mediated targeting of regulatory T cell receptors such as CTLA-4 enhances antitumor immune responses against several cancer entities including malignant melanoma. Yet, therapeutic success in patients remains variable underscoring the need for novel combinatorial approaches. Meth...

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Bibliographic Details
Main Authors: Simon Heidegger, Diana Kreppel, Michael Bscheider, Florian Stritzke, Tatiana Nedelko, Alexander Wintges, Sarah Bek, Julius C. Fischer, Theresa Graalmann, Ulrich Kalinke, Florian Bassermann, Tobias Haas, Hendrik Poeck
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419301355

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http://www.sciencedirect.com/science/article/pii/S2352396419301355

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