Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants. However, in some forms of genetic hearing impairment, the organ of Corti is structurally intact and thera...

Full description

Bibliographic Details
Main Authors: Vladan Rankovic, Christian Vogl, Nele M. Dörje, Iman Bahader, Carlos J. Duque-Afonso, Anupriya Thirumalai, Thomas Weber, Kathrin Kusch, Nicola Strenzke, Tobias Moser
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
gene therapy and therapeutic delivery
deafness/hearing loss
AAV (adeno-associated virus)
Auditory Neuroscience
otoferlin
preclinical
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.600051/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2020.600051/full

Similar Items