Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic β-Cells Is Inhibited by Unsaturated Oleic Acid

Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic β-Cells Is Inhibited by Unsaturated Oleic Acid

It has been shown that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to apoptosis, whereas unsaturated FAs are well tolerated and are even capable of inhibiting the pro-apoptotic effect of saturated FAs. Molecular mechanisms of apoptosis i...

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Bibliographic Details
Main Authors: Jan Šrámek, Vlasta Němcová-Fürstová, Nela Pavlíková, Jan Kovář
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:International Journal of Molecular Sciences
Subjects:
fatty acids
pancreatic β-cells
apoptosis
p38 mitogen-activated protein kinase (MAPK)
extracellular signal-regulated kinase (ERK)
endoplasmic reticulum (ER) stress
NES2Y
Online Access:https://www.mdpi.com/1422-0067/18/11/2313

Internet

https://www.mdpi.com/1422-0067/18/11/2313

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