Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment.

Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment.

Mammary epithelial progenitors are the normal cell-of-origin of breast cancer. We previously defined a population of p27+ quiescent hormone-responsive progenitor cells in the normal human breast whose frequency associates with breast cancer risk. Here, we describe that deletion of the Cdkn1b gene en...

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Bibliographic Details
Main Authors: Lina Ding, Lauren B Shunkwiler, Nicholas W Harper, Yang Zhao, Kunihiko Hinohara, Sung Jin Huh, Muhammad B Ekram, Jan Guz, Michael J Kern, Alexander Awgulewitsch, James D Shull, Bart M G Smits, Kornelia Polyak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6443185?pdf=render

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http://europepmc.org/articles/PMC6443185?pdf=render

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