Synthesis of a Morpholino Nucleic Acid (MNA)-Uridine Phosphoramidite, and Exon Skipping Using MNA/2′-O-Methyl Mixmer Antisense Oligonucleotide

Synthesis of a Morpholino Nucleic Acid (MNA)-Uridine Phosphoramidite, and Exon Skipping Using MNA/2′-O-Methyl Mixmer Antisense Oligonucleotide

In this study, we synthesised a morpholino nucleoside-uridine (MNA-U) phosphoramidite and evaluated the potential of a MNA-modified antisense oligonucleotide (AO) sequences to induce exon 23 skipping in mdx mouse myotubes in vitro towards extending the applicability of morpholino chemistry with othe...

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Bibliographic Details
Main Authors: Suxiang Chen, Bao T. Le, Kamal Rahimizadeh, Khalil Shaikh, Narinder Mohal, Rakesh N. Veedu
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
morpholino nucleotide
PMO
exon skipping
antisense oligonucleotide
Online Access:http://www.mdpi.com/1420-3049/21/11/1582

Internet

http://www.mdpi.com/1420-3049/21/11/1582

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