LIFR-α-dependent adipocyte signaling in obesity limits adipose expansion contributing to fatty liver disease

LIFR-α-dependent adipocyte signaling in obesity limits adipose expansion contributing to fatty liver disease

Summary: The role of chronic adipose inflammation in diet-induced obesity (DIO) and its sequelae including fatty liver disease remains unclear. Leukemia inhibitory factor (LIF) induces JAK-dependent adipocyte lipolysis and altered adipo/cytokine expression, suppressing in vivo adipose expansion in n...

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Bibliographic Details
Main Authors: Tong Guo, Arun Gupta, Jinhai Yu, Jorge Z. Granados, Aakash Y. Gandhi, Bret M. Evers, Puneeth Iyengar, Rodney E. Infante
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:iScience
Subjects:
Biological Sciences
Animal Physiology
Cellular Physiology
Endocrinology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221001954

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http://www.sciencedirect.com/science/article/pii/S2589004221001954

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