Redox-Sensitive Gelatin/Silica-Aptamer Nanogels for Targeted siRNA Delivery

Redox-Sensitive Gelatin/Silica-Aptamer Nanogels for Targeted siRNA Delivery

Abstract RNA interference (RNAi) has potential advantages over other gene therapy approaches due to its high specificity and the ability to inhibit target gene expression. However, the stability and tissue-specific delivery of siRNA remain as the biggest obstacles for RNAi therapeutics. Here, we dev...

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Bibliographic Details
Main Authors: Xueqin Zhao, Yinyin Xi, Yongming Zhang, Qiuyan Wu, Ruiyuan Meng, Bin Zheng, Lei Rei
Format: Article
Language:English
Published: SpringerOpen 2019-08-01
Series:Nanoscale Research Letters
Subjects:
siRNA delivery
Anti-nucleolin aptamer AS1411
Nucleolin targeting
Gene therapy
RNA interference
Online Access:http://link.springer.com/article/10.1186/s11671-019-3101-0

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http://link.springer.com/article/10.1186/s11671-019-3101-0

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