Secretagogin Regulates Insulin Signaling by Direct Insulin Binding

Summary: Secretagogin (SCGN) is a β-cell enriched, secretory/cytosolic Ca2+-binding protein with unknown secretory regulation and functions. Recent findings suggest that SCGN deficiency correlates with compromised insulin response and diabetes. However, the (patho)physiological SCGN-insulin nexus re...

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Bibliographic Details
Main Authors: Anand Kumar Sharma, Radhika Khandelwal, M. Jerald Mahesh Kumar, N. Sai Ram, Amrutha H. Chidananda, T. Avinash Raj, Yogendra Sharma
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900421930447X