HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha.

HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha.

BACKGROUND:Neoplastic transformation originates from a large number of different genetic alterations. Despite this genetic variability, a common phenotype to transformed cells is cellular alkalinization. We have previously shown in human keratinocytes and a cell line in which transformation can be t...

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Main Authors: Rosa A Cardone, Giovanni Busco, Maria R Greco, Antonia Bellizzi, Rosita Accardi, Antonella Cafarelli, Stefania Monterisi, Pierluigi Carratù, Valeria Casavola, Angelo Paradiso, Massimo Tommasino, Stephan J Reshkin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2568952?pdf=render

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http://europepmc.org/articles/PMC2568952?pdf=render

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