HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells

HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells

During type 1 diabetes mellitus (T1DM) development, beta-cells undergo intense endoplasmic reticulum (ER) stress that could result in apoptosis through the failure of adaptation to the unfolded protein response (UPR). Islet transplantation is considered an attractive alternative among beta-cell repl...

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Bibliographic Details
Main Authors: Vinícius M. Gomes, Rosangela A. M. Wailemann, Gabriel S. Arini, Talita C. Oliveira, Daria R. Q. Almeida, Ancély F. dos Santos, Letícia F. Terra, Stephan Lortz, Leticia Labriola
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
heat-shock proteins
diabetes mellitus
beta-cells
endoplasmic reticulum stress
proteostasis
HSPB1
Online Access:https://www.mdpi.com/2073-4409/10/9/2178

Internet

https://www.mdpi.com/2073-4409/10/9/2178

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