Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.

Bibliographic Details
Main Authors: Shingo Komura, Kenji Ito, Sho Ohta, Tomoyo Ukai, Mio Kabata, Fumiaki Itakura, Katsunori Semi, Yutaka Matsuda, Kyoichi Hashimoto, Hirofumi Shibata, Masamitsu Sone, Norihide Jo, Kazuya Sekiguchi, Takatoshi Ohno, Haruhiko Akiyama, Katsuji Shimizu, Knut Woltjen, Manabu Ozawa, Junya Toguchida, Takuya Yamamoto, Yasuhiro Yamada
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11745-1

Internet

https://doi.org/10.1038/s41467-019-11745-1

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