Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex

Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex

BackgroundRecent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic transmission by influencing chloride regulation.Case...

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Bibliographic Details
Main Authors: Chantal Vlaskamp, Simon-Shlomo Poil, Floor Jansen, Klaus Linkenkaer-Hansen, Sarah Durston, Bob Oranje, Hilgo Bruining
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Neurology
Subjects:
tuberous sclerosis complex
tuberous sclerosis complex-associated neuropsychiatric disorders
hyperexcitability
bumetanide
electroencephalography
event-related potentials
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00469/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2017.00469/full

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