Quantification and dynamic monitoring of EGFR T790M in plasma cell-free DNA by digital PCR for prognosis of EGFR-TKI treatment in advanced NSCLC.

Quantification and dynamic monitoring of EGFR T790M in plasma cell-free DNA by digital PCR for prognosis of EGFR-TKI treatment in advanced NSCLC.

Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI), about 50% carry the T790M mutation, but this frequency in EGFR-TKI-naïve patients and dynamic change during therapy remains unclear. This...

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Bibliographic Details
Main Authors: Zhijie Wang, Rui Chen, Shuhang Wang, Jia Zhong, Meina Wu, Jun Zhao, Jianchun Duan, Minglei Zhuo, Tongtong An, Yuyan Wang, Hua Bai, Jie Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4236040?pdf=render

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http://europepmc.org/articles/PMC4236040?pdf=render

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