Experimental epothilone B neurotoxicity: Results of in vitro and in vivo studies

Experimental epothilone B neurotoxicity: Results of in vitro and in vivo studies

Epothilones are a novel class of microtubule-targeting anticancer agents that are neurotoxic. In this study, we investigated the epothilone B toxic effect in vitro and we characterized in vivo the general and neurological side effects of epothilone B administration in Wistar and Fischer rats.The in...

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Bibliographic Details
Main Authors: Alessia Chiorazzi, Gabriella Nicolini, Annalisa Canta, Norberto Oggioni, Roberta Rigolio, Giacomo Cossa, Raffaella Lombardi, Ilaria Roglio, Ilaria Cervellini, Giuseppe Lauria, Roberto Cosimo Melcangi, Roberto Bianchi, Donatella Crippa, Guido Cavaletti
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Neurobiology of Disease
Subjects:
Epothilone B
In vivo
In vitro
Toxicity
Peripheral neuropathy
Tubulin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001053

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http://www.sciencedirect.com/science/article/pii/S0969996109001053

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