Experimental epothilone B neurotoxicity: Results of in vitro and in vivo studies
Epothilones are a novel class of microtubule-targeting anticancer agents that are neurotoxic. In this study, we investigated the epothilone B toxic effect in vitro and we characterized in vivo the general and neurological side effects of epothilone B administration in Wistar and Fischer rats.The in...
Main Authors: | Alessia Chiorazzi, Gabriella Nicolini, Annalisa Canta, Norberto Oggioni, Roberta Rigolio, Giacomo Cossa, Raffaella Lombardi, Ilaria Roglio, Ilaria Cervellini, Giuseppe Lauria, Roberto Cosimo Melcangi, Roberto Bianchi, Donatella Crippa, Guido Cavaletti |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2009-08-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996109001053 |
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