Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal.

Adaptive evolution in humans has rarely been characterized for its whole set of components, i.e. selective pressure, adaptive phenotype, beneficial alleles and realized fitness differential. We combined approaches for detecting polygenic adaptations and for mapping the genetic bases of physiological...

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Bibliographic Details
Main Authors: Choongwon Jeong, David B Witonsky, Buddha Basnyat, Maniraj Neupane, Cynthia M Beall, Geoff Childs, Sienna R Craig, John Novembre, Anna Di Rienzo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6143271?pdf=render