Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

Despite the introduction of biologics, topical dithranol (anthralin) has remained one of the most effective anti-psoriatic agents. Serial biopsies from human psoriatic lesions and both the c-Jun/JunB and imiquimod psoriasis mouse model allowed us to study the therapeutic mechanism of this drug. Top...

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Bibliographic Details
Main Authors: Theresa Benezeder, Clemens Painsi, VijayKumar Patra, Saptaswa Dey, Martin Holcmann, Bernhard Lange-Asschenfeldt, Maria Sibilia, Peter Wolf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
psoriasis
dithranol
anthralin
keratinocytes
AMPs
IL-36
Online Access:https://elifesciences.org/articles/56991

Internet

https://elifesciences.org/articles/56991

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