Mechanistic explanation of structural and functional changes induced by methionine mutation in G-CSF protein

Mechanistic explanation of structural and functional changes induced by methionine mutation in G-CSF protein

Potency of a biotherapeutic is influenced by its binding affinity to the designated receptor., This study examines how substitution of methionine residues with Leucine/Alanine in granulocyte colony stimulating factor (G-CSF) brings about changes in its affinity to G-CSF receptor. To this effect, two...

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Bibliographic Details
Main Authors: Avinash Mishra, Rucha S. Patil, Sumit Singh, Priyanka, Anurag S. Rathore
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Current Research in Biotechnology
Subjects:
Molecular dynamic simulation
Therapeutic protein
Mutation
Docking
Protein-protein interaction
MMPBSA energy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590262820300022

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http://www.sciencedirect.com/science/article/pii/S2590262820300022

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