Abnormal Response of the Proliferation and Differentiation of Growth Plate Chondrocytes to Melatonin in Adolescent Idiopathic Scoliosis

Abnormal Response of the Proliferation and Differentiation of Growth Plate Chondrocytes to Melatonin in Adolescent Idiopathic Scoliosis

Abnormalities in the melatonin signaling pathway and the involvement of melatonin receptor MT2 have been reported in patients with adolescent idiopathic scoliosis (AIS). Whether these abnormalities were involved in the systemic abnormal skeletal growth in AIS during the peripubertal period remain un...

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Bibliographic Details
Main Authors: William Wei-Jun Wang, Gene Chi-Wai Man, Jack Ho Wong, Tzi-Bun Ng, Kwong-Man Lee, Bobby Kin-Wah Ng, Hiu-Yan Yeung, Yong Qiu, Jack Chun-Yiu Cheng
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:International Journal of Molecular Sciences
Subjects:
idiopathic scoliosis
melatonin
growth plate
chondrocytes
proliferation
differentiation
MT2 receptor
antagonist
dysfunction
Online Access:http://www.mdpi.com/1422-0067/15/9/17100

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http://www.mdpi.com/1422-0067/15/9/17100

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