Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Abstract To identify pathogenetic markers and potential drivers of different lesion types in the white matter (WM) of patients with progressive multiple sclerosis (PMS), we sequenced RNA from 73 different WM areas. Compared to 25 WM controls, 6713 out of 18,609 genes were significantly differentiall...

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Bibliographic Details
Main Authors: Maria L. Elkjaer, Tobias Frisch, Richard Reynolds, Tim Kacprowski, Mark Burton, Torben A. Kruse, Mads Thomassen, Jan Baumbach, Zsolt Illes
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple sclerosis
Secondary progressive
Human brain lesions
Next-generation RNA sequencing
TGF-beta
CD26/DPP4
Online Access:https://doi.org/10.1186/s40478-019-0855-7

Internet

https://doi.org/10.1186/s40478-019-0855-7

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