Reciprocal Induction of MDM2 and MYCN in Neural and Neuroendocrine Cancers

Reciprocal Induction of MDM2 and MYCN in Neural and Neuroendocrine Cancers

MYC family oncoproteins MYC, MYCN, and MYCL are deregulated in diverse cancers and via diverse mechanisms. Recent studies established a novel form of MYCN regulation in MYCN-overexpressing retinoblastoma and neuroblastoma cells in which the MDM2 oncoprotein promotes MYCN translation and MYCN-depende...

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Bibliographic Details
Main Authors: Hung N. Tran, Hardeep P. Singh, Wenxuan Guo, Linda Cambier, Luke Riggan, Gregory M. Shackleford, Matthew E. Thornton, Brendan H. Grubbs, Anat Erdreich-Epstein, Dong-Lai Qi, David Cobrinik
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
MDM2
MYCN
MYC
neuroblastoma
retinoblastoma
small cell lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.563156/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.563156/full

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