ORAI channels are critical for receptor-mediated endocytosis of albumin

ORAI channels are critical for receptor-mediated endocytosis of albumin

Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.

Bibliographic Details
Main Authors: Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M. Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Stephen L. Atkin, Maria F. Gomez, Shang-Zhong Xu
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02094-y

Internet

https://doi.org/10.1038/s41467-017-02094-y

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