ORAI channels are critical for receptor-mediated endocytosis of albumin
Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.
Bibliographic Details
| Main Authors: |
Bo Zeng,
Gui-Lan Chen,
Eliana Garcia-Vaz,
Sunil Bhandari,
Nikoleta Daskoulidou,
Lisa M. Berglund,
Hongni Jiang,
Thomas Hallett,
Lu-Ping Zhou,
Li Huang,
Zi-Hao Xu,
Viji Nair,
Robert G. Nelson,
Wenjun Ju,
Matthias Kretzler,
Stephen L. Atkin,
Maria F. Gomez,
Shang-Zhong Xu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-02094-y
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