ORAI channels are critical for receptor-mediated endocytosis of albumin
Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02094-y |
| id |
doaj-d6d1cb0bcd8f49c9b88f64376cab64f6 |
|---|---|
| record_format |
Article |
| spelling |
doaj-d6d1cb0bcd8f49c9b88f64376cab64f62021-05-11T07:08:25ZengNature Publishing GroupNature Communications2041-17232017-12-018111210.1038/s41467-017-02094-yORAI channels are critical for receptor-mediated endocytosis of albuminBo Zeng0Gui-Lan Chen1Eliana Garcia-Vaz2Sunil Bhandari3Nikoleta Daskoulidou4Lisa M. Berglund5Hongni Jiang6Thomas Hallett7Lu-Ping Zhou8Li Huang9Zi-Hao Xu10Viji Nair11Robert G. Nelson12Wenjun Ju13Matthias Kretzler14Stephen L. Atkin15Maria F. Gomez16Shang-Zhong Xu17Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of HullCentre for Cardiovascular and Metabolic Research, Hull York Medical School, University of HullDepartment of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund UniversityDepartment of Renal Medicine and Hull York Medical School, Hull Royal Infirmary, Hull and East Yorkshire Hospitals NHS TrustCentre for Cardiovascular and Metabolic Research, Hull York Medical School, University of HullDepartment of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund UniversityCentre for Cardiovascular and Metabolic Research, Hull York Medical School, University of HullCentre for Cardiovascular and Metabolic Research, Hull York Medical School, University of HullKey Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical UniversityKey Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical UniversityKey Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical UniversityDepartment of Internal Medicine & Department of Computational Medicine and Bioinformatics, University of MichiganChronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthDepartment of Internal Medicine & Department of Computational Medicine and Bioinformatics, University of MichiganDepartment of Internal Medicine & Department of Computational Medicine and Bioinformatics, University of MichiganCentre for Cardiovascular and Metabolic Research, Hull York Medical School, University of HullDepartment of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund UniversityCentre for Cardiovascular and Metabolic Research, Hull York Medical School, University of HullPatients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.https://doi.org/10.1038/s41467-017-02094-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Bo Zeng Gui-Lan Chen Eliana Garcia-Vaz Sunil Bhandari Nikoleta Daskoulidou Lisa M. Berglund Hongni Jiang Thomas Hallett Lu-Ping Zhou Li Huang Zi-Hao Xu Viji Nair Robert G. Nelson Wenjun Ju Matthias Kretzler Stephen L. Atkin Maria F. Gomez Shang-Zhong Xu |
| spellingShingle |
Bo Zeng Gui-Lan Chen Eliana Garcia-Vaz Sunil Bhandari Nikoleta Daskoulidou Lisa M. Berglund Hongni Jiang Thomas Hallett Lu-Ping Zhou Li Huang Zi-Hao Xu Viji Nair Robert G. Nelson Wenjun Ju Matthias Kretzler Stephen L. Atkin Maria F. Gomez Shang-Zhong Xu ORAI channels are critical for receptor-mediated endocytosis of albumin Nature Communications |
| author_facet |
Bo Zeng Gui-Lan Chen Eliana Garcia-Vaz Sunil Bhandari Nikoleta Daskoulidou Lisa M. Berglund Hongni Jiang Thomas Hallett Lu-Ping Zhou Li Huang Zi-Hao Xu Viji Nair Robert G. Nelson Wenjun Ju Matthias Kretzler Stephen L. Atkin Maria F. Gomez Shang-Zhong Xu |
| author_sort |
Bo Zeng |
| title |
ORAI channels are critical for receptor-mediated endocytosis of albumin |
| title_short |
ORAI channels are critical for receptor-mediated endocytosis of albumin |
| title_full |
ORAI channels are critical for receptor-mediated endocytosis of albumin |
| title_fullStr |
ORAI channels are critical for receptor-mediated endocytosis of albumin |
| title_full_unstemmed |
ORAI channels are critical for receptor-mediated endocytosis of albumin |
| title_sort |
orai channels are critical for receptor-mediated endocytosis of albumin |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-12-01 |
| description |
Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3. |
| url |
https://doi.org/10.1038/s41467-017-02094-y |
| work_keys_str_mv |
AT bozeng oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT guilanchen oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT elianagarciavaz oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT sunilbhandari oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT nikoletadaskoulidou oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT lisamberglund oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT hongnijiang oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT thomashallett oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT lupingzhou oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT lihuang oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT zihaoxu oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT vijinair oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT robertgnelson oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT wenjunju oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT matthiaskretzler oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT stephenlatkin oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT mariafgomez oraichannelsarecriticalforreceptormediatedendocytosisofalbumin AT shangzhongxu oraichannelsarecriticalforreceptormediatedendocytosisofalbumin |
| _version_ |
1721452852653588480 |