Impact of <i>GSTA1</i> Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation

Impact of <i>GSTA1</i> Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation

Background: Busulfan pharmacokinetics exhibit large inter-subject variability. Our objective was to evaluate the influence of glutathione S-transferase A1 (<i>GSTA1</i>) gene variants on busulfan oral clearance (CLo) in a population of patients undergoing hematopoietic stem cell transpla...

Full description

Bibliographic Details
Main Authors: Veronique Michaud, My Tran, Benoit Pronovost, Philippe Bouchard, Sarah Bilodeau, Karine Alain, Barbara Vadnais, Martin Franco, François Bélanger, Jacques Turgeon
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Pharmaceutics
Subjects:
busulfan
glutathione S-transferase
genetic polymorphism
limited sampling strategy
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/11/9/440

Internet

https://www.mdpi.com/1999-4923/11/9/440

Similar Items