The Role of Telomere Maintenance in the Spontaneous Growth Arrest of Pediatric Low-Grade Gliomas

The Role of Telomere Maintenance in the Spontaneous Growth Arrest of Pediatric Low-Grade Gliomas

Spontaneous tumor regression is a unique feature of pediatric low-grade gliomas (PLGG). We speculated that lack of telomere maintenance is responsible for this behavior. We first looked for evidence of telomerase activity and alternative-lengthening telomeres (ALT) in 56 PLGG. Telomerase activity w...

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Bibliographic Details
Main Authors: Uri Tabori, Bisera Vukovic, Maria Zielenska, Cynthia Hawkins, Ilan Braude, James Rutka, Eric Bouffet, Jeremy Squire, David Malkin
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Telomere
telomerase
senescence
low-grade glioma
prognosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800229

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http://www.sciencedirect.com/science/article/pii/S1476558606800229

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