Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia

Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia

Endoglin is a transmembrane glycoprotein expressed in vascular endothelium that plays a key role in angiogenesis. Mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1 (HHT1), characterized by arteriovenous malformations (AVMs) in different organs. These vascular le...

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Bibliographic Details
Main Authors: Eunate Gallardo-Vara, Simon Tual-Chalot, Luisa M. Botella, Helen M. Arthur, Carmelo Bernabeu
Format: Article
Language:English
Published: The Company of Biologists 2018-09-01
Series:Disease Models & Mechanisms
Subjects:
Angiogenesis
Endoglin
HHT
AVM
TGF-β
Endothelial cells
Online Access:http://dmm.biologists.org/content/11/9/dmm034397

Internet

http://dmm.biologists.org/content/11/9/dmm034397

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