Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions. The pathogenesis underlying this syndrome remains unclear as...

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Bibliographic Details
Main Authors: Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Reczko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini
Format: Article
Language:English
Published: The Company of Biologists 2021-05-01
Series:Disease Models & Mechanisms
Subjects:
hnf1b transcription factor
rcad syndrome
gene dosage
glomerular and proximal tubule cysts
mouse models
transcriptomics
Online Access:http://dmm.biologists.org/content/14/5/dmm047498

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http://dmm.biologists.org/content/14/5/dmm047498

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