Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption

Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption

The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3 and β4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. The habenulo-interpeduncular (Hb-IPN) tract is particularly enriched in α3β4 nAChRs. We recently showed that modulation of these receptors in t...

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Bibliographic Details
Main Authors: Marta A Ślimak, Jessica L Ables, Silke eFrahm, Beatriz eAntolin-Fontes, Julio eSantos-Torres, Milena eMoretti, Cecilia eGotti, Ines eIbañez-Tallon
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Human Neuroscience
Subjects:
SNP
electrophysiological recordings
nAChR
medial habenula
nicotine consumption
lentivirus transduction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00012/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00012/full

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