Increased expression of ApoE and protection from amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA

Increased expression of ApoE and protection from amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA

Mitochondrial (mt) DNA haplogroups, defined by specific single nucleotide polymorphism (SNP) patterns, represent populations of diverse geographic origins and have been associated with increased risk or protection of many diseases. The H haplogroup is the most common European haplogroup while the K...

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Bibliographic Details
Main Authors: Kunal Thaker, Marilyn Chwa, Shari R. Atilano, Pinar Coskun, Javier Cáceres-del-Carpio, Nitin Udar, David S. Boyer, S. Michal Jazwinski, Michael V. Miceli, Anthony B. Nesburn, Baruch D. Kuppermann, M. Cristina Kenney
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neurobiology of Disease
Subjects:
Mitochondrial DNA
Haplogroup
Cybrids
APOE
Complement inhibitors
Inflammasome
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611630078X

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http://www.sciencedirect.com/science/article/pii/S096999611630078X

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