AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

Abstract Background In mammals, the AKT/PKB protein kinase family comprises three members (AKT1–3). PI3-Kinase (PI3K), a key oncogene involved in a wide variety of cancers, drives AKT activity. Constitutive activation of the PI3K/AKT pathway has been associated with tumorigenic properties including...

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Bibliographic Details
Main Authors: Sanja Brolih, Scott K. Parks, Valérie Vial, Jérôme Durivault, Livio Mostosi, Jacques Pouysségur, Gilles Pagès, Vincent Picco
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Cancer
Subjects:
Cancer
Metastasis
AKT/PKB
Head and neck squamous cell carcinoma
Phenotypic screening
Epithelial-mesenchymal transition
Online Access:http://link.springer.com/article/10.1186/s12885-018-4169-0

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http://link.springer.com/article/10.1186/s12885-018-4169-0

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