L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels

L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels

Abstract Background To investigate the effects and potential mechanism of L161982 (a kind of EP4 antagonist) on the collagen-induced arthritis (CIA) mice model. Methods The CIA mice model were first established by immunizing with Chicken Type II Collagen on DBA/1 mice. The CIA groups were administer...

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Bibliographic Details
Main Authors: Liang Chen, Xianglei Wu, Jun Zhong, Dongqing Li
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Musculoskeletal Disorders
Subjects:
Collagen-induced arthritis
Interleukin-17
Monocyte chemotactic protein-1
EP4 antagonist
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s12891-017-1819-3

Internet

http://link.springer.com/article/10.1186/s12891-017-1819-3

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