Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

Formation of a regularly branched blood vessel network is crucial in development and physiology. Here we show that the expression of the Notch ligand Dll4 fluctuates in individual endothelial cells within sprouting vessels in the mouse retina in vivo and in correlation with dynamic cell movement in...

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Bibliographic Details
Main Authors: Benedetta Ubezio, Raquel Agudo Blanco, Ilse Geudens, Fabio Stanchi, Thomas Mathivet, Martin L Jones, Anan Ragab, Katie Bentley, Holger Gerhardt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
angiogenesis
agent based modelling
neovascularization
signalling dynamics
Online Access:https://elifesciences.org/articles/12167

Internet

https://elifesciences.org/articles/12167

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