Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and <i>N</i>-Methyl-d-Aspartate Receptor Antagonists

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and <i>N</i>-Methyl-d-Aspartate Receptor Antagonists

Alzheimer’s disease (AD) is a complex disorder with unknown etiology. Currently, only symptomatic therapy of AD is available, comprising cholinesterase inhibitors and <i>N</i>-methyl-d-aspartate (NMDA) receptor antagonists. Drugs targeting only one pathological condition have generated o...

Full description

Bibliographic Details
Main Authors: Jan Konecny, Anna Misiachna, Martina Hrabinova, Lenka Pulkrabkova, Marketa Benkova, Lukas Prchal, Tomas Kucera, Tereza Kobrlova, Vladimir Finger, Marharyta Kolcheva, Stepan Kortus, Daniel Jun, Marian Valko, Martin Horak, Ondrej Soukup, Jan Korabecny
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
acetylcholinesterase
Alzheimer’s disease
butyrylcholinesterase
fluorene
in vitro
in silico
Online Access:https://www.mdpi.com/2218-273X/11/1/3

Internet

https://www.mdpi.com/2218-273X/11/1/3

Similar Items